boltz-small-molecule-design

Boltz job status and result recovery. Use when listing jobs, checking progress, resuming downloads, recovering results, or downloading an existing job ID. Not for starting new jobs.

Design new protein binders with Boltz. Use when generating protein, peptide, antibody, nanobody, or custom binder candidates for a target. Not for screening existing proteins or small molecules.

Screen existing protein binders with Boltz. Use when ranking a supplied protein, peptide, antibody, nanobody, or binder library against a target. Not for designing new proteins or screening small molecules.

Predict Tier-1 ADME/ADMET for small molecules with Boltz from bare SMILES — no target, no docking. Use when the user wants solubility, permeability, or lipophilicity/logD for a molecule or list of molecules. Not for ranking molecules against a protein target (use boltz-small-molecule-screen, which already returns ADME free).

Screen existing small-molecule libraries with Boltz. Use when docking, scoring, or ranking a supplied SMILES or compound library against a target. Not for de novo molecule design or one-off docking.

Predict structures and binding for one defined complex with Boltz. Use when folding a protein, RNA, DNA, or ligand complex, docking one ligand, predicting an interface, or scoring binding. Not for screening libraries or design.

Read first to make, edit, animate or render any video with HyperFrames (HTML rendered to video), including launch films, explainers, music videos, charts, maps, vertical clips, title cards, captions and overlays. Holds the render contract, the work loop and what each kind of video needs.

Get or make any media for a HyperFrames video - music, sound effects, images, icons, logos, voiceover, avatar and generated video, transcripts, cutouts, colour grades and looks - with HeyGen or free local tools, and mix placed audio. Also for footage that looks dark, flat or dull, or should be stylized or hidden.

Design mobile app screens with Sleek, edit Sleek projects, and implement their designs in React Native or HTML.

A relentless interview to sharpen a plan or design, which also creates docs (ADR's and glossary) as we go.

Generate AI videos with Google Veo, Seedance 2.0, HappyHorse, Wan, Grok and 40+ models via inference.sh CLI. Models: Veo 3.1, Veo 3, Seedance 2.0, HappyHorse 1.0, Wan 2.5, Grok Imagine Video, OmniHuman, Fabric, HunyuanVideo. Capabilities: text-to-video, image-to-video, reference-to-video, video editing, lipsync, avatar animation, video upscaling, foley sound. Use for: social media videos, marketing content, explainer videos, product demos, AI avatars. Triggers: video generation, ai video, text to video, image to video, veo, animate image, video from image, ai animation, video generator, generate video, t2v, i2v, ai video maker, create video with ai, runway alternative, pika alternative, sora alternative, kling alternative, seedance, happyhorse

Generate AI images with GPT-Image-2, FLUX, Gemini, Grok, Seedream, Reve and 50+ models via inference.sh CLI. Models: GPT-Image-2, FLUX Dev LoRA, FLUX.2 Klein LoRA, Gemini 3 Pro Image, Grok Imagine, Seedream 4.5, Reve, ImagineArt. Capabilities: text-to-image, image-to-image, inpainting, LoRA, image editing, upscaling, text rendering. Use for: AI art, product mockups, concept art, social media graphics, marketing visuals, illustrations. Triggers: flux, image generation, ai image, text to image, stable diffusion, generate image, ai art, midjourney alternative, dall-e alternative, text2img, t2i, image generator, ai picture, create image with ai, generative ai, ai illustration, grok image, gemini image, gpt image, openai image, chatgpt image

Create AI avatar and talking head videos via inference.sh CLI. Recommended: P-Video-Avatar (fastest, cheapest, built-in TTS). Also: OmniHuman, Fabric, PixVerse. Audio: Inworld TTS-2 (100+ languages, emotion steering for characters), ElevenLabs, Kokoro. Capabilities: audio-driven avatars, text-to-avatar, lipsync videos, talking head generation, virtual presenters, UGC content. Use for: AI presenters, explainer videos, virtual influencers, dubbing, marketing videos, UGC ads, gaming avatars, NPC dialogue. Triggers: ai avatar, talking head, lipsync, avatar video, virtual presenter, ai spokesperson, audio driven video, heygen alternative, synthesia alternative, talking avatar, lip sync, video avatar, ai presenter, digital human, ugc, ugc video, ugc ad, avatar ugc

Shared vocabulary for designing deep modules. Use when the user wants to design or improve a module's interface, find deepening opportunities, decide where a seam goes, make code more testable or AI-navigable, or when another skill needs the deep-module vocabulary.